Emerging anti-inflammatory strategies for chronic obstructive pulmonary disease
نویسندگان
چکیده
Department of Internal Medicine, Unit of Respiratory Clinical Pharmacology, University of Rome ‘Tor Vergata’, Rome, Italy Department of Pulmonary Rehabilitation, San Raffaele Pisana Hospital, IRCCS, Rome, Italy Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, London, UK Department of Experimental Medicine, Unit of Pharmacology, Second University of Naples, Naples, Italy . Published on April 10, 2012 as doi: 10.1183/09031936.00213711 ERJ Express
منابع مشابه
Association between IL6 gene polymorphism and the risk of chronic obstructive pulmonary disease in the north Indian population
Interleukin-6 (IL6) is encoded by the IL6 gene in human and acts as pro-inflammatory cytokine and an anti-inflammatory cytokine. Recent studies established that IL6 substantially contribute in the diagnosed of systemic inflammation for the patients suffering from lung diseases such as chronic obstructive pulmonary disease (COPD). Thereof, this work aimed to investigate the prot...
متن کاملThe importance of C-reactive protein and other inflammatory markers in patients with chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is a condition associated with inflammation in lungs and airways. The impacts of inflammatory process is not limited to respiratory system but extend to extrapulmonary organs with resultant complications involving endocrine, metabolic and cardiovascular systems. The extent and severity of inflammation may be partly estimated by serum measurement of s...
متن کاملHomocystein Level and Total Antioxidant Capacity in Chronic Obstructive Pulmonary Disease
Abstract Background and Objective: Oxidant-antioxidant imbalance plays a key role in pathogenesis of chronic obstructive pulmonary disease (COPD). This study aimed to evaluate homocystiene and total antioxidant capacity in COPD patients, compared to smoker and non-smoker healthy people. Material and Methods: We measured total antioxidant capacity with Cayman Kit, uric acid with Pars Azm...
متن کاملEmerging anti-inflammatory strategies for COPD.
The hallmark of chronic obstructive pulmonary disease (COPD) is an enhanced or abnormal inflammatory immune response of the lungs to inhaled particles and gases, usually from cigarette smoke, characterised by increased numbers of neutrophils, activated macrophages and activated T-lymphocytes (Tc1 and Th1 cells). Therefore, suppression of the inflammatory response is a logical approach to the tr...
متن کاملThe effects of anti-Fas ribozyme on T lymphocyte apoptosis in mice model with chronic obstructive pulmonary disease
Objective(s): In this study, we aimed to investigate the effects of anti-Fas ribozyme on the apoptosis of T lymphocytes (T cells) in mice model with chronic obstructive pulmonary disease (COPD). Materials and Methods: Male 6-week-old C57BL/6 mice were used to establish the COPD model by exposure to cigarette smoke. The COPD mice were sacrificed for spleen dissection and T cell isolation. T cell...
متن کامل